Oxygen plays a vital role in wound healing
Tap an icon to find out more
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promotes growth factor
signalling transduction
-
collagen
synthesis
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cell proliferation &
re-epithelialisation
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angiogenesis and
revascularisation
-
antibacterial
activities
- The presence of a wound increases the body’s need for oxygen by 20%. 10
- Compromised healing occurs when oxygen demand is greater than the supply.
Supplementary oxygen
can improve wound healing
- NATROX® O₂ generates and delivers continuous oxygen directly to the wound bed.
- Evidence shows oxygen plays a vital role in enabling wound healing.
Supplementary oxygen can help at any phase of wound healing
NATROX® O₂ offers the following benefits:
Continuous oxygen therapy
Generates and delivers oxygen directly to wounds 24/7. Continuous flow ensures an oxygen-rich environment.
Easy to use
Compatible with most standard of care treatments.
Supports patient compliance
Ease of use and portability means minimal disruption to patients’ lifestyle, supporting compliance.
Active therapy
Works together with existing therapies, across all patient groups and care settings.
Proven clinical efficacy
71% greater healing rates compared to standard of care alone.11 Numerous studies demonstrate the efficacy of healing using NATROX® O₂.
Fast
Quick dressing changes and minimum debridement required, helps free up your time.
Hassle free
Easy for patients to self-manage. No out-of-hour service or support required.
Patient satisfaction
90% patient satisfaction scores12, improves compliance.
See the results for yourself
Assessing if NATROX® O₂ is right for your patient
Studies show patients with a chronic wound have a 71% greater chance of healing using NATROX® O₂ than with standard of care alone.11
Topical oxygen therapy can improve both patient outcomes and quality of life.14 See for yourself why NATROX® O₂ gets 90% patient satisfaction scores.12
Move forward with NATROX® O₂
Reference List
References
[1] Kaufman, H., 2020. Portable, practical and effective: clinical benefits of Natrox topical oxygen therapy. Journal of Wound Care, 29(5):S31.
[2] Andrew J.M. Boulton, et al, 2022. New Evidence-Based Therapies for Complex Diabetic Foot Wounds. ADA Clinical Compendia 22 February 2022; 2022 (2): 1–23. Available at: https://bit.ly/3OVEidn Accessed 1 July 2022.
[3] Babior, BM (1978). Oxygen – dependent microbial killing by phagocytes. New England Journal of Medicine, 298:659-68.
[4] Lordish, H., et. al (2000). Molecular cell biology, 4th edition, New York: Freeman.
[5] Knighton, D., et al (1981). Regulation of wound healing and angiogenesis — effect of oxygen gradients and inspired oxygen concentrations. Surgery. 90:262-70.
[6] Asmis, R., et. al (2010). Low-flow oxygenation of full-excisional skin wounds on diabetic mice improves wound healing by accelerating wound closure and re-epithelialization. International Wound Journal, 7:249-57.
[7] Stephens, F., et. al (1971). Effects of changes in inspired oxygen and carbon dioxide tensions on wound tensile strength. Annals Surgery, 173:515.
[8] Sundaresan, M. et.al (1996). Regulation of reactive oxygen species generation in fibroblasts by Rac1. Biomechanical Journal, 318:379-82.
[9] Sen, CK (2003). The general case for redox control wound repair. Wound Repair Regeneration, 11:431-8.
[10] Jonsson K. Jenson JA., Goodsen WH, et. al (1991). Tissue oxygenation, anemia, and perfusion in relation to wound healing in surgical patients. Annals of Surgery, 214 (5):605-613.
[11] Serena TE, Bullock NM, Cole W et al. Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled trial. J Wound Care 2021; 30: Suppl.5 S7-14.
[12] Jones, N.C., G; Ivins, N.M.; Harding, K.G et al. (2017) The role of topical oxygen therapy in the treatment of diabetic foot ulceration. Poster in Wounds UK Harrogate, UK.
[13] Lee, A., 2022. Optimizing oxygen therapy in your clinical wound practice. Wound Masterclass Vol 1, June 2022. [online] Available at: https://woundmasterclass.com/ [Accessed 15 July 2022].
[14] Gottrup, F. 2020. Portable, practical and effective: clinical benefits of NATROX® topical oxygen therapy. Journal of Wound Care May 2020, 29(5):53.
[15] Samanatha Tate. Head of Podiatry, Westmead Hospital, Australia. BSc (Hons) Podiatry, Accredited Lymphoedema Practitioner, Grad Cert. Clinical Lead. Dec 2023.
[16] Bem, R., Chadwick, P., Cvjetko, I., et al, 2023. A new algorithm for the management of diabetic foot ulcers: recommendations from Central and Eastern Europe. Journal of Wound Care, 32(S), p.264-70. Available at: https://bit.ly/nwc-tot-algorithm-JWCMay23
[17] Lavery, L. A. et al. WHS (Wound Healing Society) guidelines update: Diabetic foot ulcer treatment guidelines. Wound Repair and Regeneration (2023) doi:10.1111/wrr.13133.
[18] Health Technology Wales, 2022. Health Technology Wales (HTW) Guidance 043 (Sep 2022). (online) Available at: https://bit.ly/nwc_HTWSepGuidance
[19] Kaufman, H., Gurevich, M., Tamir, E., et al., 2021. Topical oxygen therapy used to improve wound healing in a large retrospective study of wounds of mixed aetiology. Wounds International, 12(2) pp.62-8.
[20] Carter, M.J., Frykberg, R.G., Oropallo, A., et al., 2022. Efficacy of Topical Wound Oxygen Therapy in Healing Chronic Diabetic Foot Ulcers: Systematic Review and Meta-Analysis. Adv Wound Care, doi: 10.1089/wound.2022.0041.
[21] Chen et al, 2023. IWGDF DFU Wound Healing Interventions Guideline (2023 update). Available at: https://bit/ly/nwc-iwgdf-guidelines2023
[22] Serena T.E., Andersen, C., Cole, W., et al., 2022. Guidelines for the use of topical oxygen therapy in the treatment of hard-to-heal wounds based on a Delphi consensus. J Wound Care, 31(Sup3) pp.S20-S24. doi: 10.12968/jowc.2022.31.Sup3.S20. PMID: 35199564.
[23] Lee, A., 2022. Optimizing oxygen therapy in your clinical wound practice. Wound Masterclass, 1, pp.61-4. [online] Available at: <https://woundmasterclass.com> [Accessed 15 July 2022].
[24] Jebril, W., Nowak, M., Palin, L., et al., 2022. Topical oxygen treatment relieves pain from hard-to-heal leg ulcers and improves healing: a case series. J Wound Care, 31(1) pp.4-11
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