Enhancing Wound Healing Using NIRS: Continuous Topical Oxygen Therapy Case Series


In a new study published in Wounds (May 2024), Dr. Windy Cole and Dr. Emma Woodmansey explored the effectiveness of Continuous Topical Oxygen Therapy (cTOT) in treating chronic nonhealing wounds. The study, titled “Monitoring the Effect of Continuous Topical Oxygen Therapy With Near-Infrared Spectroscopy: A Pilot Case Series in Wound Healing”, offers compelling evidence of the benefits of cTOT.

Key Findings

This pilot case series involved five patients with nonhealing wounds, treated over five weeks. The results were promising:

  • Significant Reduction in Wound Area: All patients showed reductions in wound area, with three patients achieving complete healing within the study period.
  • Improved Tissue Oxygenation: Near-infrared spectroscopy (NIRS) revealed increased tissue oxygenation in all patients, correlating with wound healing progress.
  • Pain Reduction: Patients reported reduced pain levels with cTOT, enhancing their overall quality of life.

Study Insights

The study highlighted the critical role of oxygen in wound healing, especially in chronic conditions where tissue oxygen levels are compromised. By using NIRS, the researchers could objectively measure and track tissue oxygenation, providing valuable insights into the efficacy of cTOT.

Why Continuous Topical Oxygen Therapy?

cTOT delivers continuous oxygen directly to the wound bed, enhancing the healing environment. This innovative approach supports:

  • Faster Healing: Accelerates the wound healing process by improving tissue oxygenation.
  • Noninvasive Treatment: Offers a noninvasive alternative to traditional methods, making it suitable for a wide range of patients.
  • Convenient Use: The portable and easy-to-use device allows patients to maintain their daily activities uninterrupted.

Read the Full Study

To dive deeper into the findings and methodologies of this study, read the full article published in Wounds. Click here to access the publication.

Learn More About cTOT

Interested in how Continuous Topical Oxygen Therapy can benefit your patients? Visit our NATROX® O₂ product page to explore our innovative solutions and discover how we are transforming wound care.


This pilot case series underscores the potential of cTOT as a pivotal adjunct therapy for chronic wound management. By integrating advanced technologies like NIRS, healthcare providers can make informed decisions and optimize patient outcomes.

Authors: Windy Cole, DPM, CWSP; Emma Woodmansey, PhD

Published in: Wounds, May 2024

DOI: 10.25270/wnds/23150