NATROX® O₂ stimulates healing in difficult chronic wounds: a tertiary centre experience

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Publication: Journal of Wound Care, 2018

Authors: Hanna Kaufman, Maxim Gurevich, Eran Tamir, Elad Keren, Lipkin Alexander, Paul Hayes

Keywords: Chronic wound, home care, new technology, tertiary centre, topical oxygen, wound healing

Key points:

  • 100-patient case series study carried out in Israel – “real world setting.”
  • Mixed aetiology wounds.
  • Mean wound duration of 15 months.
  • All wounds previously unsuccessfully treated with standard of care (SoC).
  • Broad inclusion criteria: No size limits, osteomyelitis included, acute infection excluded.
  • Complete wound closure was observed in 32% of the total study group
  • Optimal wound healing occurred when treated with NATROX® O₂ for ≥ 25 days.
    • 57% of arterial/DFUs healed when treated for ≥ 25 days
    • 47% of VLUs healed when treated for ≥ 25 days
  • Demonstrates NATROX® O₂ should be used for a prolonged period. If used for ≥ 25 days there is a significantly greater reduction in wound size 76% compared with 39%.
  • 88% adherence to therapy, with average treatment duration 40.3 days.
  • Wound size was a factor in healing. Larger wounds take longer to heal.
  • Non-concordant / non-compliant patients were removed for the analysis.
  • Discusses ATP production and how increased oxygen = improved healing, which adds a slightly different slant
  • Discusses different ways of delivering oxygen, highlighting any negatives.
  • Contains a great visual illustration of issues with wound hypoxia.
  • Discusses why wound hypoxia is an issue in arterial and DFUs, and how it can be a significant issue in VLUs as well.
  • Introduces the concept that even if you achieve healing, the quality can be poor due to low oxygen levels.