Topical oxygen therapy for chronic wounds: a report on the potential of NATROX® a new device for delivering enriched oxygen to chronic wounds

Introduction to Topical Oxygen Therapy (TOT) for Chronic Wounds

In a seminal exploration of venous ulcers’ pathogenesis, it was discovered that tissues around these ulcers exhibited remarkably low transcutaneous oxygen (TCPO2) levels, despite pulsatile dermal blood supply. This finding prompted a deeper investigation into the impaired microcirculation and molecular entrapment in ulcerated tissue, leading to the proposition of topical oxygen therapy (TOT) as a potential solution.

Gordillo and Sen elucidated the mechanistic underpinnings of TOT, highlighting its role in collagen production, angiogenesis, and the scavenging process essential for wound repair. Insights from experimental wounds paved the way for clinical studies aimed at evaluating the safety and efficacy of TOT in chronic wound management.

Clinical Studies and Safety Evaluation

Safety evaluation of NATROX® O₂ was conducted through two pivotal studies. The initial study, conducted at Southampton University Hospital Trust, demonstrated the device’s safety profile over a 6-week period in patients with venous disease and chronic wounds. Subsequently, an observational study involving ten patients, led by Tissue Viability Nurses at Tissue Viability Consultancy Services Ltd (TVCS), evaluated the safety and recorded changes in wound area over 6 weeks of NATROX® O₂ usage.

Results and Expert Opinion

The clinical studies reported no adverse events associated with NATROX® O₂ usage. A statistically significant reduction in wound areas (mean reduction of 58.9%) and pain scores was observed across the patient cohort. Expert opinion underscores the potential of NATROX® O₂ in safely and effectively treating chronic lower extremity wounds, offering hope for improved patient outcomes.

Patient Case Studies

Detailed patient case studies further illustrate the real-world impact of NATROX® O₂ in chronic wound management. From reduction in wound size to alleviation of pain, these cases provide compelling evidence of NATROX® O₂’s efficacy in diverse patient populations.

Reference: Mani R. (2010) Topical oxygen therapy for chronic wounds: a report on the potential of NATROX™ a new device for delivering enriched oxygen to chronic wounds. J Wound Technol, 9(3):28-30.