Topical Oxygen Therapy Meta-Analyses

Effects of Oxygen Therapy on Patients with a Chronic Wound: A Systematic Review and Meta-analysis

Systematic review and meta-analysis of 31 RCTs including 1,823 patients.

Key findings:

Pooled effects of 31 included studies showed that patients treated with oxygen:

  • had better short-term wound healing (risk ratio [RR], 1.544; 95% CI, 1.199 to 1.987)
  • a higher percentage reduction in the ulcer area (standardized mean difference [SMD], 0.999; 95% CI, 0.439 to 1. 599)
  • lower amputation rates (RR, 0.529; 95% CI, 0.325 to 0.862)
  • shorter wound healing time (SMD, −0.705; 95% CI, −0.908 to −0.501)
  • higher post-study TcPO2 (SMD, 2.128; 95% CI, 0.978 to 3.278) than those in the control group.

Citation: Du X, Zhang X, Liu J, et al. (2024) Effects of Oxygen Therapy on Patients with a Chronic Wound: A Systematic Review and Meta-analysis. Adv Skin Wound Care, 37(5):1-9.

Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: An updated systematic review and meta-analysis

Systematic review and meta-analysis of 7 DFU RCTs including 614 patients.

Key findings:
  • Existing evidence suggests that TOT is effective and safe for chronic DFUs.
  • Compared with the control group, the TOT group had a higher healing rate (RR=1.63, 95% CI 1.33, 2.00, p<.00001).

Citation: Sun XK, Li R, Yang XL, et al. (2022) Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: An updated systematic review and meta-analysis. Int Wound J, 19(8):2200-9.

Topical oxygen therapy for healing diabetic foot ulcers: A systematic review and meta-analysis of randomized control trials

Systematic review and meta-analysis of 4 DFU RCTs including 492 patients.

Key findings:
  • TOT increased the likelihood of healing by 59% within 12 weeks.
  • Use of adjunctive TOT significantly increased the healing rate (RR: 1.59; 95% Cl: 1.07, 2.37; p<0.02).

Citation: Sethi A, Khambhayta Y, Vas P. (2022) Topical oxygen therapy for healing diabetic foot ulcers: A systematic review and meta-analysis of randomized control trials. Health Sci Rev, 3(2022-Jun):100028.

Efficacy of topical wound oxygen therapy in healing chronic diabetic foot ulcers: Systematic review and meta-analysis

Systematic review and meta-analysis of 4 DFU RCTs including 494 patients.

Key findings:
  • TOT recognized as a potential adjunctive therapy for the treatment of DFUs.
  • Random-effects meta-analysis of four RCTs showed that TOT improved wound healing at 12-weeks over SOC alone (RR: 1.59; 95% Cl: 1.07-2.37; p=0.021).
  • Overall GRADE level of evidence for TOT was moderate.

Citation: Carter M, Frykberg RG, Oropallo A, et al.(2022) Efficacy of Topical Wound Oxygen Therapy in Healing Chronic Diabetic Foot Ulcers: Systematic Review and Meta-Analysis. Adv Wound Care, 12(4):177-86.

Topical oxygen therapy for diabetes-related foot ulcers: A systematic review and meta-analysis

Systematic review and meta-analysis of 6 DFU RCTs including 530 patients.

Key findings:
  • Meta-analysis suggests TOT significantly increased the likelihood of ulcer healing compared to controls (RR=1.94, 95% CI 1.19, 3.17; I2=57%; NNT=5.33).

Citation: Thanigaimani S, Singh T, Golledge J.
(2021) Topical oxygen therapy for
diabetes- related foot ulcers: A systematic
review and meta-analysis. Diabet Med,
2021;00:e14585.

Impact of topical oxygen therapy on diabetic foot ulcer healing rates: a systematic review

Systematic review and meta-analysis of 4 DFU RCTs.

Key findings:
  • DFUs are >2x more likely to heal with TOT than SOC alone.
  • Time to 50% DFU closure was significantly shorter for participants who received TOT.
  • OR=2.49 (95% CI 1.59-3.90, p=.00001).

Citation: Connaghan F, Avsar P, Patton D, et al.
(2021) Impact of topical oxygen therapy
on diabetic foot ulcer healing rates: a
systematic review. [Abstract] J Wound
Care
, 30(10):823-9.