Evidence

43$ of DFU Patients also have Peripheral Artery Disease (PAD)
Breaking Barriers in Peripheral Artery Disease (PAD) and Diabetic Foot Ulcer (DFU) Care
Case series looking at the use of topical oxygen therapy to treat diabetic foot ulcers
Case Series Examining the Efficacy of cTOT in Treatment of DFUs
Article on clinical trial about the use of topical oxygen therapy to heal diabetic foot ulcers
TOT in the Treatment of DFUs: Randomised controlled clinical trial (RCT)
Brochure on background and wound care for non-healing diabetic foot ulcers
Case Study: Healing a Non-Healing Diabetic Foot Ulcer (DFU)
Case series on use of the NATROX® O₂ device for healing diabetic foot ulcers
Case series: Using NATROX® O₂ in management of DFUs
NATROX® O₂ case study – UK experience with DFUs
NATROX® O₂ Case Reports: Evaluating the outcomes of 8 DFU patients
NATROX® O₂ – breakthrough in managing non-healing DFUs
The use of NATROX® O₂ topical oxygen therapy on patients with recalcitrant DFUs
Challenging wounds, improving outcomes – Treatment of complex DFUs
TOT promotes the healing of chronic DFUs: pilot study
Case series: the impact of NATROX® O₂ on patients with DFUs
Mechanistic Insights and International Use Cases of cTOT in Wound Management
Efficacy of continuous topical oxygen therapy in hard-to-heal wounds in Colombia Journal of Wound Care Article
Topical Oxygen Therapy in the Management of Hard-to-Heal Wounds in Colombia: A Retrospective Review
American Diabetes Association (ADA) Standards of Care in Diabetes 2026
Use of Continuous Topical Oxygen Therapy in Combination to Optimize the Chronic Wound Environment Prior to Cellular, Acellular, and Matrix-Like Product Application
Use of Continuous Topical Oxygen Therapy in Combination to Optimize the Chronic Wound Environment Prior to Cellular, Acellular, and Matrix-Like Product Application: A Retrospective Case Series
Supplemental Oxygen Therapy in Wound Healing
Supplemental Oxygen Therapy in Wound Healing
Supplemental Oxygen Therapy in Wound Healing
Percentage area reduction at week 4 as a prognostic indicator of complete healing in patients treated with standard of care: a post hoc analysis
The Use of cTOT in Combination with Cellular, Acellular and Matrix-like Products to Treat Complex, Chronic Wounds: a Retrospective Case Series
A model for diabetic foot ulcer clinical trials on advanced therapies
Effect of NATROX on Rates of Healing Chronic DFU
An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox™) on the Rates of Healing of Chronic Diabetic Foot Ulcers
Topical Oxygen Therapy Meta-Analyses
The Efficacy of Continuous Topical Oxygen Therapy in the Treatment of Challenging Diabetic Foot Ulcers; A Case Series
IWGDF Guidelines Support Topical Oxygen Therapy (TOT)
Poster by an expert on eliminating barriers in wound care
Barriers Eliminated: An Advanced Digital Wound Platform Combined with Continuous Topical Oxyen Therapy Improves Access, Saves Time, and Decreases Wound Size in Complex Diabetic Patients
A new algorithm for the management of diabetic foot ulcer: recommendations from Central and Eastern Europe
Report on an expert opinion on topical oxygen therapy for wound care
Expert Opinion in Support of TOT
Report on Delphi Consensus on guidelines for the use of topical oxygen therapy
Delphi Consensus on Guidelines for the Use of Topical Oxygen
A multicenter clinical trial evaluating the durability of diabetic foot ulcer healing in ulcers treated with topical oxygen and standard of care versus standard of care alone 1 year post healing
Continuous Topical Oxygen Therapy – Improving Healing in the Diabetic Foot
Topical oxygen therapy results in complete wound healing in diabetic foot ulcers
Clinical article on the shift of microbiome dynamics that is created by topical oxygen therapy when treating diabetic foot ulcers
Topical Oxygen Therapy Shifts Microbiome Dynamics in Chronic Diabetic Foot Ulcers
NATROX® O₂ topical oxygen wound therapy: A vital element in wound healing
NATROX® O₂ stimulates healing in difficult chronic wounds: a tertiary centre experience
The role of topical oxygen therapy in the treatment of diabetic foot ulceration

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