Evidence

American Diabetes Association (ADA) Standards of Care in Diabetes 2026

TOT receives an “A grade” recommendation for the fourth year as an adjunctive treatment for chronic DFUs based its strength of evidence.

WHS (Wound Healing Society) guidelines update: Diabetic foot ulcer treatment guidelines

International Consensus: Use of Topical Oxygen Therapy in Wound Healing – JoWC Sep 2023

Consensus on the Clinical Efficacy and Guidelines of Continuous Topical Oxygen Therapy for Wounds – JoWC LATAM Oct 2023

IWGDF Guidelines Support Topical Oxygen Therapy (TOT)

A new algorithm for the management of diabetic foot ulcer: recommendations from Central and Eastern Europe

Delphi Consensus on Guidelines for the Use of Topical Oxygen

Health Technology Wales Guidance

Consensus round table meeting: Clinical pathway for using TOT

This document was created by clinical specialists within the UK, to provide health care professionals with the relevant information needed to select and use NATROX® Oxygen Wound Therapy appropriately in clinical practice.