Key Points

  • Severe injuries in theater and early post-evacuation often present with compromised perfusion, hypoxia, and high risk of infection.
  • Without early intervention, necrosis progresses, wounds stall, and amputation risk increases.
  • In trauma wounds, oxygen is often the missing element.
  • Continuous topical oxygen therapy (cTOT) delivers oxygen directly to the wound site.
  • NATROX® O₂ supports tissue repair, angiogenesis, and infection control
  • NATROX O₂ is ideal for military settings.

Topics Covered

  • The critical window of treating combat and operational wounds.
  • The role of oxygen in wound healing and tissue repair.
  • Clinical evidence supporting cTOT
  • Case examples
  • NATROX O₂’s value for the DoD
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References

  1. U.S. Medicine. (2025) Nonhealing wounds from battlefield injuries, chronic conditions, and surgery present significant medical challenges. https://www.usmedicine.com/clinical-topics/battlefield-medicine/nonhealing-wounds-from-battlefield-injuries-chronic-conditions-surgery-create-medical-challenges/
  2. Frykberg RG, Banks J. (2015) Challenges in the Treatment of Chronic Wounds. Adv Wound Care (New Rochelle), 4(9):560-582. https://journals.sagepub.com/doi/10.1089/wound.2015.0635
  3. Serena TE, Bullock NM, Cole W, et al. (2021) Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled trial. J Wound Care, 30(Sup5):s7-14. https://www.natroxwoundcare.com/wp-content/uploads/JoWC_2021_30_05_SerenaRCT_Web-Lic.pdf
  4. Castilla DM, Liu ZJ, Velazquez OC. (2012) Oxygen: Implications for Wound Healing. Adv Wound Care (New Rochelle), (6):225-230. https://pmc.ncbi.nlm.nih.gov/articles/PMC3625368/
  5. Ball C, Jones H, Thomas H, et al. (2024) Impact of continuous topical oxygen therapy on biofilm gene expression in a porcine tissue model. J Wound Care, 33(9):702-707. https://www.natroxwoundcare.com/wp-content/uploads/NATROX-O2-cTOT-Biofilm-Gene-Expression.pdf
  6. Cole W, Woodmansey E. (2024) Monitoring the Effect of Continuous Topical Oxygen Therapy with Near-Infrared Spectroscopy: A Pilot Case Series in Wound Healing. Wounds, 36(5):154-9. https://www.natroxwoundcare.com/wp-content/uploads/Cole_Monitoring-the-Effect-of-cTOT-with-NIRS.pdf
  7. Al-Jalodi O, Kupcella M, Breisinger K, et al. (2022) A multicenter clinical trial evaluating the durability of diabetic foot ulcer healing in ulcers treated with topical oxygen and standard of care versus standard of care alone 1 year post healing. Int Wound J, 19(7):1-5. https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.13789
  8. Frykberg R, Andersen C, Chadwick P, et al. (2023) Use of topical oxygen therapy in wound healing. J Wound Care, 32(S8B) S3-30. https://www.natroxwoundcare.com/wp-content/uploads/JoWC_Oxygen-Consensus_July202023.pdf
  9. Data on file.
  10. Lee A. (2023) Barriers Eliminated: An Advanced Digital Wound Platform Combined with Continuous Topical Oxyen Therapy Improves Access, Saves Time, and Decreases Wound Size in Complex Diabetic Patients. [Poster] SAWC Spring: Orlando. https://www.natroxwoundcare.com/resource/barriers-eliminated-dr-lee-poster-sawc-spring-2023/
  11. Data on file.
  12. Wongprachum B. Data on file.