Front page of NATROX O2 continuous topical oxygen therapy global leave piece

Key Points

  • Problem: Chronic, non-healing wounds due to insufficient wound perfusion.
  • Solution: Topical Oxygen Therapy (cTOT)
  • Method: ContinuousTopical Oxygen Therapy (cTOT) with NATROX® O₂

Topics Covered

  • Indicated wound types
  • When to consider NATROX® O₂
  • How NATROX® O₂ provides patient-centric care and wound care efficiency
  • How to apply
  • What to expect
  • Supporting evidence

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References

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  2. Nauta TD, van Hinsbergh VWM, Koolwijk P. (2014) Hypoxic signaling during tissue repair and regenerative medicine. Int J Mol Sci, [e-journal] 15(11):19791-815.
  3. Sun XK, Li R, Yang XL, et al. (2022) Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: An updated systematic review and meta-analysis. Int Wound J, 19(8):2200-9.
  4. Carter M, Frykberg RG, Oropallo A, et al. (2022) Efficacy of Topical Wound Oxygen Therapy in Healing Chronic Diabetic Foot Ulcers: Systematic Review and Meta-Analysis. Adv Wound Care, 12(4):177-86.
  5. Sethi A, Khambhayta Y, Vas P. (2022) Topical oxygen therapy for healing diabetic foot ulcers: A systematic review and meta-analysis of randomized control trials. Health Sci Rev, 3(2022-Jun):100028.
  6. Thanigaimani S, Singh T, Golledge J. Topical oxygen therapy for diabetes-related foot ulcers: A systematic review and meta-analysis. Diabet Med, 2021;00:e14585.
  7. Connaghan F, Avsar P, Patton D, et al. (2021) Impact of topical oxygen therapy on diabetic foot ulcer healing rates: a systematic review. [Abstract] J Wound Care, 30(10):823-9.
  8. Kaufman H, Gurevich M, Tamir E, et al. (2018) Topical oxygen therapy stimulates healing in difficult, chronic wounds: a tertiary centre experience. J Wound Care, 27(7):426–33.
  9. Yu J, Lu S, McLaren AM, et al. (2016) Topical oxygen therapy results in complete wound healing in diabetic foot ulcers. Wound Repair Regen, 24:1066-72.
  10. Kaufman H, Gurevich M, Tamir E, et al. (2021) Topical oxygen therapy used to improve wound healing in a large retrospective study of wounds of mixed aetiology. Wounds Int, 12(2):62-8.
  11. Goncalves V, Schofield A. (2024) Continuous Topical Oxygen Therapy Made Easy. Wounds Int. Link.
  12. Lee A, O’Leary JL, Klopfenstein B. (2022) Using CTOT and leveraging a digital platform, changes how and when we deliver wound care while optimizing both clinical outcomes and limited resources. [Poster presentation] DFCon: Los Angeles. Link.
  13. Serena TE, Bullock NM, Cole W, et al. (2021) Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled trial. J Wound Care, 30(Sup5):s7-14.
  14. Jebril W, Nowak M, Palin L, et al. (2022) Topical oxygen treatment relieves pain from hard-to-heal leg ulcers and improves healing: a case series. J Wound Care, 31(1):4-11.
  15. Wahab N, Cole W. (2024) The Use of Continuous Topical Oxygen Therapy in Combination with Cellular, Acellular and Matrix-like Products to Treat Complex, Chronic Wounds: A Retrospective Case Series. [Poster] SAWC Spring: Orlando. Link.
  16. Kaufman H. (2020) Portable, practical and effective: clinical benefits of Natrox topical oxygen therapy. J Wound Care, 29(5):s31.
  17. Consensus round table meeting: Topical oxygen therapy for healing complex wounds. (2018) London: Wounds International, Available at
    www.woundsinternational.com.
  18. Jones N, Curran G, Ivins N, et al. (2017) The role of topical oxygen therapy in the treatment of diabetic foot ulceration. [Poster] Wounds UK: Harrogate. Link.
  19. Lee A, Woodmansey E, Klopfenstein B, et al. (2024) Remote assessments and monitoring with advanced wouth therapy to optimise clinical outcomes, access, and resources. J Wound Care, 33(2):90-101.
  20. Al-Jalodi O, Kupcella M, Breisinger K, et al. (2022) A multicenter clinical trial evaluating the durability of diabetic foot ulcer healing in ulcers treated with topical oxygen and standard of care versus standard of care alone 1 year post healing. Int Wound J, 19(7):1-5.
  21. American Diabetes Association Professional Practice Committee (2025) Standards of Care in Diabetes. Diabetes Care, 48(Supplement_1):S259.
  22. International Working Group on the Diabetic Foot- IWGDF. (2023) Guidelines on interventions to enhance healing of foot ulcers in people with diabetes. IWGDF Guidelines, May 2023.
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