Key Points

  • Patients suffering from chronic wounds and associated pain are often negatively impacted by declining mental health and a reliance on opioids, which can contribute to increased suicide risks.

Topics Covered

  • Alignment between the VA and NATROX® O₂ missions to improve quality of life and reduce the use of opioids for pain.
  • Evidence supporting NATROX® O₂’s impact on pain reduction, mental health, and quality of life.
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References

  1. Cole W, Woodmansey E. (2023) Supporting the Patient Journey. Podiatry M, Nov/Dec:77-84.
  2. Benavidez GA, Zahnd WE, Hung P, et al. (2024) Chronic Disease Prevalence in the US: Sociodemographic and Geographic Variations by Zip Code Tabulation Area. Prev Chronic Dis, 21:230267. 
  3. Probst S, Gschwind G, Murphy L, et al. (2023) Patients ‘acceptance’ of chronic wound-associated pain – A qualatative descriptive study. J Tissue Viability, 32(4):455-9.
  4. Renner R, Erfurt-Berge C. (2017) Depression and quality of life in patients with chronic wounds: ways to measure their influence and their effect on daily life. Chronic Wound Care Manag Res, 4:143-51.
  5. Department of Veterans Affairs (2020) Managing Chronic Pain May Protect Against Suicide Risk.
  6. Department of Veterans Affairs (2022) Department of Veterans Affairs Fiscal Years 2022-28 Strategic Plan.
  7. Jebril W, Nowak M, Palin L, et al. (2022) Topical oxygen treatment relieves pain from hard-to-heal leg ulcers and improves healing: a case series. J Wound Care, 31(1):4-11.
  8. Molina W, Pérez Camacho K, Cole W, et al. (2025) Efficacy of continuous topical oxygen therapy in hard-to-heal wounds in Colombia. J Wound Care, 34(5):S15-24.
  9. Silvestrini S. (2019) Supplementary oxygen and wound healing. Wounds Int, 10(4):50-6.
  10. Testimonial. Data on file.
  11. Manavabasi P, Foster L. (2025) When Conventional Treatment Fails: A Wearable Continuous Topical Oxygen Therapy System Reduces Wound Volume in Chronic Venous Leg Ulcers. [Poster] SAWC Fall.
  12. Testimonial.
  13. Bailey-Davies S, Quddus A, Younis N, et al. (2024) Promoting Healing of Chronic Wounds Using Continuous Topical Oxygen Therapy with Chronic Limb Threatening Ischaemia Having No Revascularisation Option: a Case Study. [Poster] Wounds UK.