Evidence

How the VA Can Save Over $1.2 Billion on Diabetic Foot Ulcer Care

Health Economics: Cost Effectiveness of Continuous Topical Oxygen Therapy for Unhealed Diabetic Foot Ulcers within the United States Veterans Health Administration presented at SAWC Fall 2026.

Topical Oxygen Therapy for Wound Bed Optimization Prior to Planned Skin Substitute Application: A Four-Patient Case Series

Complex lower-extremity wounds being prepared for skin substitutes. Four patient case series poster presented by Dr. Edward C. Kormylo at SAWC Fall 2026.

Case Study Examining the Efficacy of Continuous Topical Oxygen Therapy in Managing Chronic Ischemic Wounds Associated with Buerger’s Disease

Non-healing ischemic ulcer of the left hallux healed at 22 weeks. Poster presented by Dr. Joseph Larsen at SAWC Spring 2026.

Mechanistic Insights and International Use Cases of cTOT in Wound Management

Article by Dr. Windy Cole et al in Wounds International 2025: cTOT is a promising, globally adaptable therapy for chronic and complex wounds.

Continuous Topical Oxygen Therapy (cTOT) Used to Support Healing of a Recalcitrant Donor Site Wound

Poster by Mr. Norbert Kang et al / BAPRAS 2025: 5-year recalcitrant donor site wound achieved full closure within 8 months of cTOT treatment.

International Consensus Document – Cellular, Acellular and Matrix-Like Products (CAMPs) in Pressure Injuries

Article by Davenport T, Dirks R, Kelso M, et al. (2025) An International Consensus Document stats that wounds may require regenerative interventions to promote repair, such as topical oxygen therapy and CAMPs.

Breaking Barriers in Peripheral Artery Disease (PAD) and Diabetic Foot Ulcer (DFU) Care

The integration of cTOT and digital health solutions represents a turning point in PAD and DFU care. Clinical Insight published September 2025.

Exploring the Efficacy of Continuous Topical Oxygen Therapy for Diverse Chronic Wound Types: Real-World Case Studies

Poster and Video presented by Dr. Windy Cole at SAWC Fall September 2025: cTOT has proven effective in promoting wound healing across diverse wound types in complex patients worldwide.

When Conventional Treatment Fails: A Wearable Continuous Topical Oxygen Therapy System Reduces Wound Volume in Chronic Venous Leg Ulcers

Poster presented by Manavabasi P, Foster L. (2025) SAWC Fall: cTOT as an essential complement to standard of care for non-healing VLUs.

Healing a Chronic Venous Leg Ulcer with NATROX® O₂

VLU Patient Testimonial July 2025

After 5 Years of Struggle, NATROX® O₂ Healed Her Mom’s Wound

Caregiver Testimonial July 2025

Why Robust Wound Healing Matters for Prosthetic Users: The Role of Continuous Topical Oxygen Therapy

Case Study by Dr. Windy Cole: A non-healing 22 week below knee amputation (BKA) stump wound achieved wound closure after only 3 weeks of therapy.

Antimicrobial Resistance in Wound Care

Expert Panel Consensus Statements by Cole W, Woodmansey EA. Podiatry Management 2025: Topical Oxygen Therapy has been shown to enhance antimicrobial efficacy.

Shared Decision-Making in Wound Management

Clinical Insight by Dr. Windy Cole discusses shared-decision making and patient-centered care in wound management.

Topical Oxygen Therapy in the Management of Hard-to-Heal Wounds in Colombia: A Retrospective Review

Poster by Windy Cole, DPM, Wolmark Xiques Molina, MD, Katrwin Melissa Pérez Camacho, Thomas Serena, MD and Corresponding Journal of Wound Care for first cohort study to examine cTOT on patients in Colombia.

Continuous Topical Oxygen Therapy Used in a Nursing Home Setting to Promote Closure of a Non-Healing Pressure Ulcer: A Case Study

Case Study by Jane Hampton and Lisa Thomas: Non-healing Category 3 Pressure Ulcer healed in 67 days

A Complex Surgical Wound Dehiscence Case Managed with Continuous Topical Oxygen Therapy

Poster presented at Wound Care Today, Telford, UK 2025. cTOT was used to help achieve full closure in a complex SWD in 5 weeks.

A Veteran’s Triumph Over Non-Healing Wounds with NATROX® O₂

Veteran Patient Testimonial 2025

American Diabetes Association (ADA) Standards of Care in Diabetes 2026

TOT receives an “A grade” recommendation for the fourth year as an adjunctive treatment for chronic DFUs based its strength of evidence.

Use of Continuous Topical Oxygen Therapy in Combination to Optimize the Chronic Wound Environment Prior to Cellular, Acellular, and Matrix-Like Product Application: A Retrospective Case Series

Case Series by Naz Wahab, MD; Windy Cole, DPM; and Emma Woodmansey, PhD showing that cTOT proved to be an effective way to improve the quality of the wound bed, in addition to standard cleansing and debridement before CAMP application.

How NATROX® O₂ Saved My Leg: A Testimonial of Hope and Healing

Patient Testimonial 2024

Breathing Life Into Wounds

Article by Andrea Valentino, Page 26 Practical Patient Care Nov 2024

Topical Oxygen Therapy in Hard to Heal Wound – A Serial Case Study

Promoting Healing of Chronic Wounds Using cTOT in a Patient with Chronic Limb Threatening Ischaemia Having No Revascularisation Option

Supplemental Oxygen Therapy in Wound Healing

Percentage area reduction at week 4 as a prognostic indicator of complete healing in patients treated with standard of care: a post hoc analysis

Impact of Continuous Topical Oxygen Therapy on Wound Moisture Levels

Continuous Topical Oxygen Therapy as Part of the Reconstructive Ladder of Limb Salvation: a Case Series

Impact of Continuous Topical Oxygen Therapy on Fluid Handling

Antimicrobial Resistance Stewardship in Wound Management

Combination therapy for a non-healing VLU

After 3 long years, this patient finally experienced full wound closure using continuous topical oxygen therapy in combination with CAMPs.

Topical Oxygen Therapy in Hard-to-Heal Wounds in Cardiac Surgery

Measuring the Effect of Continuous Topical Oxygen Therapy Case with Near Infrared Spectroscopy (NIRS)

The Use of cTOT in Combination with Cellular, Acellular and Matrix-like Products to Treat Complex, Chronic Wounds: a Retrospective Case Series

The role of cTOT as an adjunctive treatment in non-healing chronic wounds; A South African perspective

Impact of continuous Topical Oxygen Therapy on biofilm gene expression in a porcine tissue model

Breaking Ground in Wound Healing: The Rise of Topical Oxygen Therapy

MedTech Marvel: Harnessing the Healing Power of Oxygen

Quick Guide to Continuous Topical Oxygen Therapy (cTOT)

M.O.I.S.T. Concept for the Local Therapy of Chronic Wounds: An International Update

Managing Wound Pain: International Perspectives on Assessments, Challenges and Treatment Options

Unlocking Wound Healing Potential: Insights on NATROX® O₂ Therapy with Dr. Windy Cole, DPM, CWSP

Continuous Topical Oxygen Made Easy

A model for diabetic foot ulcer clinical trials on advanced therapies

Innovating Wound Healing: Roundtable Talk on Continuous Topical Oxygen Therapy

Decoding Topical Oxygen Therapy & Wound Biofilms: Insights from Dr. Gregory Schultz, Biofilm Expert

Transforming Wound Care: Harnessing Continuous Topical Oxygen Therapy (cTOT) in Clinical Practice

Managing Chronic Wound Pain with Topical Oxygen Therapy: Insights from Dr. Windy Cole